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Course title |
合成生物學
Synthetic Biology - Design, Engineering and Evolution |
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Semester |
106-2 |
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Designated for |
COLLEGE OF LIFE SCIENCES INSTITUTE OF LIFESCIENCE |
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Instructor |
周信宏 |
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Curriculum Number |
LS5085 |
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Curriculum Identity Number |
B21 U2290 |
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Class |
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Credits |
2.0 |
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Full/Half
Yr. |
Half |
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Required/
Elective |
Elective |
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Time |
Thursday 7,8(14:20~16:20) |
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Room |
生科1148 |
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Remarks |
與吳承、黃筱鈞共授
The upper limit of the number of students: 18. |
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Ceiba Web Server |
http://ceiba.ntu.edu.tw/1062LS5085_ |
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Course introduction video |
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Table of Core Capabilities and Curriculum Planning |
Association has not been established |
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Course Syllabus
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Please respect the intellectual property rights of others and do not copy any of the course information without permission
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Course Description |
課堂中將講授基因選殖、誘變、演化篩選、電腦模擬與基因迴路的設計原理，介紹並討論經典與近期的合成生物學研究報告，學生將依研究興趣及專長分組於期末提出新的合成生物學方法或應用。 |
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Course Objective |
學生暸解合成生物學的原理及應用，透過獨立思考及團隊合作構思嶄新的實驗技術、分析方法、以及在生技產業上的應用價值。 |
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Course Requirement |
1.學生須事前閱讀教材並於課堂上積極參與討論。
2.學生須已修習普通生物學以及下列任一課程：生物化學、分子生物學、遺傳學、細胞生物學、微生物學、計算機程式設計、生物資訊學
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Student Workload (expected study time outside of class per week) |
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Office Hours |
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Designated reading |
待補 |
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References |
1.Synthetic Biology (Methods in Molecular Biology 1073), 2013
2.An Introduction to Systems Biology: Design Principles of Biological Circuits, by Uri Alon (Chapman & Hall/CRC Mathematical & Computational Biology), 2006.
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Grading |
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No. |
Item |
% |
Explanations for the conditions |
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1. |
期末口頭報告 |
20% |
小組 16 分鐘口頭報告, 4 分鐘答辯 |
2. |
小組研究計畫書 |
25% |
4/12: 一頁
6/16: 至多六頁 |
3. |
口頭報告二 |
20% |
小組 40 分鐘口頭報告 |
4. |
口頭報告一 |
20% |
小組 40 分鐘口頭報告 |
5. |
課程參與 |
15% |
出席、參與討論 |
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Week |
Date |
Topic |
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第1週 |
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[Video] Introduction of synthetic biology |
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第2週 |
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[Lecture_Chou] Methodology of cloning, mutagenesis, and selection |
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第3週 |
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[Lecture_Huang] Analysis and design of genetic networks |
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第4週 |
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[Lecture_Wu] Synthetic biology meets application |
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第5週 |
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[LP _Chou] Computational design of regulatory elements |
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第6週 |
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民族掃墓節 |
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第7週 |
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[LP _Chou] Deep mutational scanning |
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第8週 |
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[LP _Chou] Directed evolution of proteins |
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第9週 |
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[LP _Chou] Metabolic engineering |
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第10週 |
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[Discussion] Proposing the team project |
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第11週 |
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[LP _Huang] Design principles of biochemical oscillators |
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第12週 |
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[LP _Huang] Network motif and polarity |
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第13週 |
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[LP _Huang] Genetic circuits for cellular computation |
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第14週 |
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[LP _Wu] Cell-cell communications |
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第15週 |
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[LP _Wu] Engineering cells as therapeutics |
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第16週 |
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[LP_Wu] Genome manipulation through CRISPR |
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第17週 |
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Team project presentation |