課程名稱 |
基因體學 Genomics |
開課學期 |
112-2 |
授課對象 |
生命科學院 生命科學所 |
授課教師 |
丁照棣 |
課號 |
LS5080 |
課程識別碼 |
B21 U2240 |
班次 |
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學分 |
3.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期四8,9,10(15:30~18:20) |
上課地點 |
生科419 |
備註 |
與麥德倫、林友瑜合授 總人數上限:30人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
Recent advances in genomics have significantly revolutionized the ways which we do science in the 21st century. With the completion of the human genome, the new genome technologies have transformed our ability to understand the structure and function of genomes and to explore the genomes of multicellular organisms. This course is designed to introduce undergraduate students, who are interested in this exciting and rapidly evolving field, the basic knowledge of genome and the state-of-the-art genome technologies. The lectures will cover an introduction on genome projects, sequencing technologies, genetic variation, transcriptomics, proteomics, functional genomics, comparative genomics, metagenomics and epigenomics. |
課程目標 |
The aim for this course is to provide students an up-to-date knowledge in genome science at the introductory level and act as a bridging course to the more advanced levels. In addition to basic genome sciences, participating undergraduates will learn to annotate genes and other features, leading to address scientific questions in genomics and research publication. |
課程要求 |
All students should have taken introductory level genetics. If you do not have any background in genetics or biology, please talk with the instructor in advance. |
預期每週課後學習時數 |
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Office Hours |
另約時間 備註: Appointments by e-mail |
指定閱讀 |
All readings will be provided weekly. |
參考書目 |
Genetics and Genomics Medicine by Tom Strachan (Garland Science , 2015)
Introduction to Genomics by Arthur M. Lesk (2nd Edition, Oxford University Press, 2011)
A Primer of Genome Science by G. Gibson and S. V. Muse (3rd Edition, Sinauer, 2009)
Dictionary of DNA and genome technology by P. Singleton (Wiley-Blackwell, 2010)
Evolutionary Genomics and Proteomics Edited by M. Pagel and A. Pomiankowski (Sinauer Associates, 2007)
From Genes to Genomes: Concepts and Applications of DNA Technology by J. W. Dale and M. van Schantz (John Wiley & Sons, 2007) [2002 Ed. available through NTU library]
Foundations of comparative genomics by Arcady R. Mushegian (Academic Press, 2007)
Genome Science: A Practical and Conceptual Introduction to Molecular Genetic Analysis in Eukaryotes by David Micklos (CSHL Press, 2013) |
評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
Week 1 |
02/22 |
Introduction (Lin) |
Week 2 |
02/29 |
DNA Sequencing Technologies (Lin) |
Week 3 |
03/07 |
The Human Genome Project (Lin) |
Week 4 |
03/14 |
Mapping, Sequencing, Annotation (Lin) |
Week 5 |
03/21 |
Databases (Lin) |
Week 6 |
03/28 |
Genome Variation (Mai) |
Week 7 |
04/04 |
No class (Holiday) |
Week 8 |
04/11 |
Gene Expression and the Transcriptome (Mai) |
Week 9 |
04/18 |
Proteomics and Systems Biology (Mai) |
Week 10 |
04/25 |
The Impact of Genomes on Human Health and Diseases (Mai) |
Week 11 |
05/02 |
From Personal Genetics to Consumer Genomics (Ting) |
Week 12 |
05/09 |
Student's presentation on Stories of Personal Genomics (5 min-presentation)
Genetic Testing and Gene Therapy (Ting) |
Week 13 |
05/16 |
Genomics and Anthropology (Ting) |
Week 14 |
05/23 |
Metagenomics and eDNA (Invited speaker) |
Week 15 |
05/30 |
Functional Genomics (Ting) |
Week 16 |
06/06 |
Final Examination Period |
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