課程名稱 |
細胞訊息傳導 Cellular Signaling |
開課學期 |
109-2 |
授課對象 |
生命科學院 生命科學所 |
授課教師 |
李士傑 |
課號 |
LS5102 |
課程識別碼 |
B21EU2460 |
班次 |
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學分 |
2.0 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期一3,4(10:20~12:10) |
上課地點 |
生科3C |
備註 |
本課程以英語授課。 總人數上限:15人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1092LS5102_ |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
The course objective is to understand how cells respond to environmental
signals and relay the signals from cellular membrane through cytoplasm to
nucleus. Membrane, cytoplasm or nuclear receptors accept signals and transmit
them by modulating downstream signaling pathways that lead to the activation
or inhibition of effectors, which in turn trigger specific cellular
responses. Any defects in the pathway may lead to the malfunction in cellular
responses. Therefore, it is important to understand each individual steps and
their links through the signaling for the proper cellular functions. We will
discuss the characteristics of receptor families and learn about their
signaling pathways and subsequent cellular responses. Furthermore, signaling
pathways can be independent or linked to form the complicated signaling
network. |
課程目標 |
The purpose of this class is not to overwhelm you with the complexity of
cellular signaling, which may be true in nature, but to have you learn the
basis of known important pathways with the potential complexity in mind. This
course is given in English for the purpose of learning science in English. |
課程要求 |
one test (30%), one oral presentation (30%), one report (30%) and class performance (10%). |
預期每週課後學習時數 |
|
Office Hours |
另約時間 |
指定閱讀 |
待補 |
參考書目 |
Text: Cell Signalling, 2/e 2005, John Hancock, Oxford
University Press
Supplements: Gomperts et al., 2002. Signal Transduction,
Academic Press, New
York.; Heldin and Purton, 1998, Signal Transduction;
Hardie, Biochemical
Messengers and selected journal articles. |
評量方式 (僅供參考) |
No. |
項目 |
百分比 |
說明 |
1. |
Class Performance |
20% |
|
2. |
report |
40% |
|
3. |
oral presentaion |
40% |
|
|
週次 |
日期 |
單元主題 |
第1週 |
03/02 |
Overview of Cellular Signaling |
第2週 |
03/09 |
First Messengers |
第3週 |
03/16 |
Receptors |
第4週 |
03/23 |
G protein transducers |
第5週 |
03/30 |
Effectors & Intracellular Calcium |
第6週 |
04/06 |
Protein Phosphorylation: Kinases & Phosphatases |
第7週 |
04/13 |
Receptor Tyrosine Protein Kinases & Non-receptor Tyrosine Kinases |
第8週 |
04/20 |
Adhesion Molecules & WNT signaling |
第9週 |
04/27 |
Activation of the Innate Immune System : The Toll-Like Receptor-4 and Signaling through Ubiquitinylation |
第10週 |
05/04 |
Signaling through the Insulin Receptor : Phosphoinositide 3-Kinases, PKB and AKT |
第11週 |
05/11 |
TGF帣 and Signaling through Receptor Serine/Threonine Protein Kinases |
第12週 |
05/18 |
Cell Fate Determination by Notch |
第13週 |
05/25 |
Student Presentation |
第14週 |
06/01 |
Student Presentation |
第15週 |
06/08 |
Student Presentation |
第16週 |
06/15 |
Student Presentation |
第17週 |
06/29 |
Reports |
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