Course Information
Course title
 分子生物學
Molecular Biology 
Semester
 102-1 
Designated for
 COLLEGE OF LIFE SCIENCES  DEPARTMENT OF BIOCHEMICAL SCIENCE AND TECHNOLOGY  
Instructor
 張麗冠 
Curriculum Number
 BST5010 
Curriculum Identity Number
 B22 U0200 
Class
  
Credits
 4 
Full/Half
Yr.
 Half 
Required/
Elective
 Required 
Time
 Monday 3,4(10:20~12:10) Thursday 3,4(10:20~12:10) 
Room
 普203普402 
Remarks
 與黃楓婷、廖憶純、林晉玄合開
The upper limit of the number of students: 80. 
Ceiba Web Server
 http://ceiba.ntu.edu.tw/1021_BSTMB 
Course introduction video
 
Table of Core Capabilities and Curriculum Planning
 Table of Core Capabilities and Curriculum Planning
Course Syllabus
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Course Description

本課程為生技系大三學生的必修課程，首先介紹染色體的結構與組成，進而導引進入DNA的複製，重組與修復。之後以Central Dogma的理論架構，介紹基因的表現，包含轉錄，RNA 修飾，與轉譯等過程。最後介紹基因的調控與分子生物學的技術。
 

Course Objective
 藉由具系統性的課程內容及深入淺出的授課方式，使學生徹底瞭解分子生物學之重要理論及機制，並深植生技研究與應用發展的基礎。 
Course Requirement
  
Student Workload (expected study time outside of class per week)
  
Office Hours
  
Designated reading
  
References
 *1. Watson, J. D., Baker, T. A., Bell, S. P., Gann, A., Levine, M. and Losick, R. (2014) Molecular Biology
of the Gene. 7th ed. Cold Spring Harbor Laboratory Press, New York.
2. Lewin, B. (2007) Genes XI. Jones & Bartlett Publishers, Inc.
3. Weaver, R. F. (2008) Molecular Biology. 4th ed. McGraw-Hill Companies, Inc.
4. Nelson, D. L. and Cox, M. M. (2008) Lehninger Principles of Biochemistry. 5th ed. W. H. Freeman
and Company, New York.

 
Grading
    
Progress
Week
Date
Topic
第1週
 9/09, 9/12  Introduction,
Genome structure 廖憶純 
第2週
 9/16  Regulation of chromatin structure, The replication of DNA 廖憶純 
第3週
 9/23, 9/26  The replication of DNA 廖憶純 
第4週
 9/30, 10/03  The replication of DNA; Nucleosome assembly 廖憶純 
第5週
 10/7  Exam 1 廖憶純 
第6週
 10/14, 10/17  DNA damage and DNA repair 黃楓婷 
第7週
 10/21, 10/24  Homologous recombination 黃楓婷 
第8週
 10/28, 10/31  Site-specific recombination; Transposition 黃楓婷 
第9週
 11/4, 11/7  Techniques of molecular biology 黃楓婷; Mechanisms of transcription 林晉玄 
第10週
 11/11, 11/14  Exam 2 黃楓婷; Mechanisms of transcription 林晉玄 
第11週
 11/18, 11/21  RNA splicing 林晉玄 
第12週
 11/25, 11/28  Translation 林晉玄 
第13週
 12/2, 12/5  The Genetic Code 林晉玄; Transcriptional regulation in prokaryotes 張麗冠 
第14週
 12/9, 12/12  Exam 3 林晉玄; Transcriptional regulation in prokaryotes 張麗冠 
第15週
 12/16, 12/19  Transcriptional regulation in eukaryotes 張麗冠 
第16週
 12/23, 12/26  Control of translation 張麗冠 
第17週
 12/30, 1/2  Regulatory RNAs 張麗冠 
第18週
 1/6/2014  Exam 4 張麗冠