課程資訊
課程名稱
 結構生物學概論
Introduction to Structural Biology 
開課學期
 107-1 
授課對象
 生命科學院  生化科技研究所  
授課教師
 楊啟伸 
課號
 BST5008 
課程識別碼
 B22EU0180 
班次
  
學分
 2.0 
全/半年
 半年 
必/選修
 必修 
上課時間
 星期四6,7(13:20~15:10) 
上課地點
 農化二B10 
備註
 本課程以英語授課。碩士班A群組必修10學分課程之一。
總人數上限：80人 
Ceiba 課程網頁
 http://ceiba.ntu.edu.tw/1071BST5008_sb 
課程簡介影片
 
核心能力關聯
 本課程尚未建立核心能力關連
課程大綱
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課程概述

This is a class integrates the concepts of structural biology and bioinformatics. The basic principle of amino acids and structre will be explained first, then the modern methods to resolve atomic resolution of protein structures. The relation of protein structure and function will be emphasized in the third part of this class. Bioinformatic principles, methods and modern developments will be followed. 

課程目標
 1. Understand amino acids and protein structures.
2. Modern approaches to resolve protein structure.
3. Protein structure and function.
4. Software-based analysis of protein sequence.
5. Bioinformatic theories
6. Current developments of protein structural-related bioinformatics methods. 
課程要求
 This class will be taught in English. 
預期每週課後學習時數
  
Office Hours
  
指定閱讀
 待補 
參考書目
 1. David Whitford (2005). Proteins : Structure and Function. John Wiley & Sons, Hoboken, NJ. USA.
2. Gregory A. Petsko and Dagmar Ringe (2003). Protein Structure and Function, 4th ed., New Science Press, Waltham, MA.
3. Materials are updated when new developments occur. 
評量方式
(僅供參考)
  
No.
項目
百分比
說明
1. 
 Mid-term 
30% 
 Written Exam 
2. 
 Presentation 
20% 
 Presentation of an assigned topic in Engilsh 
3. 
 Personal Report 
20% 
 Protein structural analysis with software tools taught in this class 
4. 
 Final Exam 
30% 
 Written Exam, Take-home/Open-book style 
 
課程進度
週次
日期
單元主題
第1週
 9/14  1. Concepts of structural biology
2. What will be taught in this class 
第2週
 9/21  Software tools
Amino Acids (1/2) 
第3週
 9/28  Amino Acids (2/2)
Amino Acids as Basic Elements In Protein Structure(1/2)  
第4週
 10/5  1. Amino Acids as Basic Elements In Protein Structure(2/2)
2. Five different basic structural elements: Alpha helix, Beta sheet, Beta turn, Beta bulge and Loop
2. Protein Structure Classification Systems: SCOP and CATH 
第5週
 10/12  What are proteins doing inside the cells?
PyMol "select" command 
第6週
 10/19  1. Functional Domains
2. Motif
3. Protein Conformational Changes

Resolving protein structures (I):
1) Whole picture of current methods
2) X-ray diffraction/NMR/CryoEM (Single particle analysis) 
第7週
 10/26  Resolving protein structures (II):
1) X-ray diffraction (1/2): Crystal growing and Diffraction 
第8週
 11/01  1. Resolving protein structures (III):
X-ray diffraction (2/2)
2. CyroEM
3. Considerations of Protein Structural Resolving: Which Method to Use? 
第9週
 11/08  Midterm Exam 
第10週
 11/15  No classes (a break from the exhausted midterm exam study?)
Happy birthday, NTU!
Let's do some sports!
 
第11週
 11/23  BYOC (Bring your own computer) day:
0. *** Form Groups for Presentation ***
1. Structure Resolving: A Review
2. All about PDB file
3. Let's play with those software to make movie! 
第12週
 11/29  Structural Biology and Bioinformatics: Structural prediction by pen and paper
Swiss Model and SOSUI 
第13週
 12/06  Structural Biology and Life Science:
1. Mutation
2. Surface accessing area
3. FAQ for presentation
4. Membrane proteins
5. Presentation demo 
第14週
 12/13  Structural Biology and Life Science:
Group 1a and 1b
Group 2a and 2b 
第15週
 12/20  Structural Biology and Life Science:
3. Photoreceptors
Group 3a and 3b 
第16週
 12/27  Structural Biology and Life Science:
4. Signal transduction through G-protein
Group 4a and 4b 
第17週
 1/03  Structural Biology and Life Science:
5. Signal transduction in two-component system
Group 5a and 5b