課程資訊
課程名稱
基因體學
Genomics 
開課學期
101-1 
授課對象
生命科學院  生命科學系  
授課教師
丁照棣 
課號
MCB5014 
課程識別碼
B43EU1250 
班次
 
學分
全/半年
半年 
必/選修
必修 
上課時間
星期四7,8,9(14:20~17:20) 
上課地點
生科4B 
備註
本課程以英語授課。B群選擇必修。
總人數上限:50人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1011Genomics 
課程簡介影片
 
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課程概述

Recent advances in genomics have significantly revolutionized the ways which we do science in the 21st century. With the completion of the human genome, the new genome technologies have transformed our ability to understand the structure and function of genomes and have enabled scientists to explore the genomes of multicellular organisms. This course is designed to introduce undergraduate students, who are interested in this exciting and rapidly evolving field, the basic knowledge of genome and the state-of-the-art genome technologies. The lectures will cover an introduction on genome projects, sequencing technologies, genetic variation, transcriptome, proteomics, functional genomics, evolutionary genomics, metagenomics and epigenomics, plus 3 guest lectures on the application of genomic tools in addressing biological questions. 

課程目標
The aim for this course is to provide students an up-to-date knowledge in genome science at the introductory level and act as a bridging course to the more advanced levels. 
課程要求
All students should have taken general biology, genetics or equivalent courses. Regular attending is expected. The instructor will give two-hour lecture and leave one hour as the discussion section. Students are expected to read the paper and actively participating in the discussion. 
預期每週課後學習時數
 
Office Hours
每週一 08:30~10:30 
參考書目
 
指定閱讀
A Primer of Genome Science by G. Gibson and S. V. Muse (Sinauer, 2004)
Genomes 3 by T. A. Brown (Garland Science, 2007)
(2nd Ed. available at NCBI, http://www.ncbi.nlm.nih.gov/books/NBK21128/)
 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Homework 
60% 
 
2. 
Presentation 
25% 
 
3. 
Discussion 
15% 
 
 
課程進度
週次
日期
單元主題
第1週
9/13  Introduction/ genome and genome project 
第2週
9/20  The Human Genome Project 
第3週
9/27  Genome Projects: Organization and Objectives 
第4週
10/04  Genome Sequencing 
第5週
10/11  DNA sequence technologies 
第6週
10/18  Genome Annotation 
第7週
10/25  SNPs and Variation 
第8週
11/01  Gene Expression and Transcriptome 
第9週
11/08  Functional Genomics 
第10週
11/15  Epigenomics 
第11週
11/22  Evolution and comparative genomics 
第12週
11/29  Functional proteomics – protein identification and annotation 
第13週
12/06  Metabolomics 
第14週
12/13  Gene Network and Systems Biology 
第15週
12/20  Guest Lecture 
第16週
12/27  Guest Lecture 
第17週
1/03  Guest Lecture