課程名稱 |
分子演化 MOLECULAR EVOLUTION |
開課學期 |
98-2 |
授課對象 |
生命科學院 生態學與演化生物學研究所 |
授課教師 |
丁照棣 |
課號 |
EEB5048 |
課程識別碼 |
B44 U1600 |
班次 |
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學分 |
2 |
全/半年 |
半年 |
必/選修 |
選修 |
上課時間 |
星期三2,3(9:10~11:10) |
上課地點 |
生科4C |
備註 |
與王弘毅合開 總人數上限:20人 |
Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/982ME |
課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
課程大綱
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課程概述 |
This course is designed for undergraduate level students who are interested in molecular evolution or bioinformatics related topics. Students who have some knowledge of biology and/or genetics are preferred. The instructors will introduce the dynamics of evolutionary change at the molecular level, the driving forces govern the evolutionary process, the effects of the various molecular mechanisms on the structure of genes, proteins, and genomes, the methodology involved in dealing with molecular data from an evolutionary perspective, and the logic of molecular hypothesis testing.
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課程目標 |
In combination with the computer laboratory practice, we aim to help our students to understand the evolutionary processes at the molecular level. |
課程要求 |
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預期每週課後學習時數 |
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Office Hours |
另約時間 備註: by appointment |
指定閱讀 |
Fundamentals of Molecular Evolution, Second Edition by Dan Graur and Wen-Hsiung Li (Sinauer, 1999) |
參考書目 |
Bioinformatics and Molecular Evolution by Paul Higgs and Teresa Attwood (Wiley-Blackwell, 2005)
Computational Molecular Evolution by Ziheng Yang (Oxford University Press, 2006)
Inferring Phylogenies (Paperback) by Joseph Felsenstein (Sinauer, 2003)
Molecular Evolution and Phylogenetics by Masatoshi Nei and Sudhir Kumar (Oxford University Press, 2000)
Molecular Evolution by Wen-Hsiung Li (Sinauer Associates, 1997)
Molecular Evolution: A Phylogenetic Approach by Roderick D.M. Page and, Edward C. Holmes (1991, Wiley-Blackwell)
Phylogenetic Trees Made Easy: A How-to Manual, Third Edition by Barry G. Hall (Sinauer, 2007)
Statistical Methods in Molecular Evolution by Rasmus Nielsen (Springer, 2005)
The Phylogenetic Handbook: A Practical Approach to DNA and Protein Phylogeny Ed. by Marco Salemi and Anne-Mieke Vandamme (Cambridge University Press, 2003)
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評量方式 (僅供參考) |
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週次 |
日期 |
單元主題 |
第1週 |
2/24 |
Introduction, Chapter 1: Genes, Genetic Codes, and Mutation
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第2週 |
3/03 |
Chapter 2: Dynamics of Genes in Populations |
第3週 |
3/10 |
Chapter 3: Evolutionary Change in Nucleotide Sequences |
第4週 |
3/17 |
Chapter 3: Evolutionary Change in Nucleotide Sequences |
第5週 |
3/24 |
Chapter 4: Rates and Patterns of Nucleotide Substitution |
第6週 |
3/31 |
Chapter 4: Rates and Patterns of Nucleotide Substitution |
第7週 |
4/07 |
Spring Break |
第8週 |
4/14 |
Midterm (Chapter 1-4) |
第9週 |
4/21 |
Chapter 5: Molecular Phylogenetics |
第10週 |
4/28 |
Chapter 5: Molecular Phylogenetics |
第11週 |
5/05 |
Neutral and Adaptive Evolution |
第12週 |
5/12 |
Neutral and Adaptive Evolution |
第13週 |
5/19 |
Gene Duplication and Evolution of Genome Size |
第14週 |
5/26 |
Genome Evolution   |
第15週 |
6/02 |
Guest Lecture |
第16週 |
6/09 |
Review Section |
第17週 |
6/16 |
Final Examination |
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