課程資訊
課程名稱
醣質生物學
Glycobiology 
開課學期
108-2 
授課對象
生命科學院  生化科學研究所  
授課教師
邱繼輝 
課號
BChem7019 
課程識別碼
B46 M1240 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期二8,9(15:30~17:20) 
上課地點
生化N101 
備註
與林俊宏、安形高志、呂桐睿合授
總人數上限:50人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1082BChem7019_ 
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課程概述

This course aims to teach the fundamentals of glycobiology inclusive of aspects on functional glycomics, chemical and translational glycobiology. It is partly based on the recently updated textbook “Essentials of Glycobiology 3rd edition”, which is freely available on the NCBI bookshelf, and supplemented by other materials extracted from recent original research and review articles on relevant subject matters. The first module will introduce all common forms of glycosylation that collectively make up the cell surface glyco-code, with emphasis on their generic structures, biosynthesis and known functional implications. The second module aims at introducing the various proteins that recognize, bind and mediate the functions of glycans, in the context of infection and immunity. The final module will then reiterate the chemistry underlying the various glycans and how chemical glycobiology can be effectively applied for diverse range of translational research, including strategies in developing glyco-based therapeutics and vaccines. Students are also taught the common experimental approaches in glycobiology through interactive discussion of assigned reading materials and oral presentations. Course assessment will be based on these presentations and Q&A during the discussion seminar scheduled towards end of the classes. 

課程目標
讓學生全面性了解細胞醣化修飾的結構與功能、醣生物學在生醫的重要性與應用性,以及一般常用的實驗方法與切入點 
課程要求
生物、生化相關領域背景,開放一般大學部與研究所學生 
預期每週課後學習時數
 
Office Hours
 
參考書目
Essentials of Glycobiology 3rd Ed 
指定閱讀
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
3/03  General aspects of GBP and C-type Lectin 
第2週
3/10  No Class 
第3週
3/17  Galectins – outside and inside 
第4週
3/24  Siglecs and Sialylation 
第5週
3/31  A Primer on Carbohydrate Structure and Conformation 
第6週
4/07  Carbohydrate Synthesis – Protecting groups 
第7週
4/14  Chemical and Enzymatic Glycosidic Bond Formation 
第8週
4/21  Mid Term Exam 
第9週
4/28  Chemical and Translational Glycobiology I 
第10週
5/05  Chemical and Translational Glycobiology II 
第11週
5/12  Chemical and Translational Glycobiology III 
第12週
5/19  Protein Glycosylation - from ER to Golgi 
第13週
5/26  Diverse range of O-glycosylation 
第14週
6/02  Analytical and Functional Glycomics 
第15週
6/09  Seminars: Glycosylation in Diseases and Cancer 
第16週
6/16  Seminars: Glyco recognition in Immunity 
第17週
6/23  Seminars: Chemical Glycobiology Applications