課程資訊
課程名稱
醣質生物學
Glycobiology 
開課學期
110-2 
授課對象
生命科學院  生化科學研究所  
授課教師
邱繼輝 
課號
BChem7019 
課程識別碼
B46EM1240 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期三8,9(15:30~17:20) 
上課地點
生化N101 
備註
本課程以英語授課。與林俊宏、安形高志、呂桐睿合授
總人數上限:50人 
 
課程簡介影片
 
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課程概述

THIS COURSE AIMS TO TEACH THE FUNDAMENTALS AND APPLICATIONS OF GLYCOBIOLOGY IN THE BROADER CONTEXT OF FUNCTIONAL GLYCOMICS, BASED ON THE RECENTLY UPDATED TEXTBOOK “ESSENTIALS OF GLYCOBIOLOGY 2ND EDITION”, WHICH IS FREELY AVAILABLE ON THE NCBI BOOKSHELF, AND OTHER WEB MATERIALS ON THE NATURE FUNCTIONAL GLYCOMICS GATEWAY. FROM THE CAUSE AND CONSEQUENCES OF ONCO-DEVELOPMENTAL CHANGES IN GLYCOSYLATION TO PROTEINS THAT RECOGNIZE, BIND AND MEDIATE THE FUNCTIONS OF GLYCANS, STUDENTS ARE INTRODUCED TO ESSENTIAL CONCEPTS AND RECENT DEVELOPMENTS IN THE FIELD. CURRENT PURSUE IN BOTH BASIC RESEARCH AND MEDICAL APPLICATIONS, INCLUDING THE HISTORICAL DEVELOPMENT OF NEURAMINIDASE INHIBITORS (E.G. TAMIFLU) AND GLYCANS INVOLVED IN VIRAL INFECTIONS ARE DISCUSSED IN THE CONTEXT OF WHAT CHEMICAL APPROACHES ARE AVAILABLE TO GLYCOBIOLOGISTS FOR DIAGNOSTICS AND THERAPEUTICS. SEMINARS ARE ORGANIZED FOR STUDENTS IN GROUPS TO PRESENT AND DISCUSS KEY ORIGINAL RESEARCH PAPERS, WHICH TOGETHER WITH FOLLOWING UP WRITTEN REPORT, WILL CONSTITUTE THE PRINCIPAL COURSE WORK AND ASSESSMENT. 

課程目標
本課程旨在讓學生了解醣化學的概論並使他們能夠:1)自信地閱讀此領域的文獻,2)為以後深入此領域的研究做好準備。 
課程要求
學生將依學期末的演講被評分。此外,學生必須出席所有的課程,包括其他同學的演講。曠課超過兩節課的學生,其等第被降低的細節如下:三次曠課–降低三分之一個等第(如A–至B+);四次曠課–降低一個完整的等第(如A–至B–);五次曠課–降低兩個等第(如A–至C–);六次或以上曠課–課程不及格。 
預期每週課後學習時數
 
Office Hours
 
參考書目
ESSENTIALS OF GLYCOBIOLOGY 2ND EDITION 
指定閱讀
 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2/16  A Primer on Carbohydrate Structure and Conformation授課老師:Todd 
第2週
2/23  Protein Glycosylation – From ER to Golgi授課老師:Khoo 
第3週
3/02  Diverse range of O-glycosylation授課老師:Khoo 
第4週
3/09  Analytical and Functional Glycomics授課老師:Khoo 
第5週
3/16  Microbial Glycans and Biophysical Methods授課老師:Todd 
第6週
3/23  General aspects of GBP and Galectins授課老師:Angata 
第7週
3/30  C-type Lectins授課老師:Angata 
第8週
4/06  Siglecs and Sialylation授課老師:Angata 
第9週
4/13  Chemical Glycosidic Bond Formation授課老師:Todd 
第10週
4/20  Chemical and Translational Glycobiology I授課老師:Hans 
第11週
4/27  Chemical and Translational Glycobiology II授課老師:Hans 
第12週
5/04  Chemical and Translational Glycobiology III授課老師:Hans 
第13週
5/11  Student Presentation, Q&A, and Commentary by professor授課老師:All 
第14週
5/18  Student Presentation, Q&A, and Commentary by professor授課老師:All 
第15週
5/25  Student Presentation, Q&A, and Commentary by professor授課老師:All 
第16週
6/01  Student Presentation, Q&A, and Commentary by professor授課老師:All