課程資訊
課程名稱
醣質生物學
Glycobiology 
開課學期
109-2 
授課對象
生命科學院  生化科學研究所  
授課教師
邱繼輝 
課號
BChem7019 
課程識別碼
B46EM1240 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期二8,9(15:30~17:20) 
上課地點
生化N101 
備註
本課程以英語授課。與林俊宏、安形高志、呂桐睿合授
總人數上限:50人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1092BChem7019_ 
課程簡介影片
 
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課程概述

THIS COURSE AIMS TO TEACH THE FUNDAMENTALS AND APPLICATIONS OF GLYCOBIOLOGY IN THE BROADER CONTEXT OF FUNCTIONAL GLYCOMICS, BASED ON THE RECENTLY UPDATED TEXTBOOK “ESSENTIALS OF GLYCOBIOLOGY 2ND EDITION”, WHICH IS FREELY AVAILABLE ON THE NCBI BOOKSHELF, AND OTHER WEB MATERIALS ON THE NATURE FUNCTIONAL GLYCOMICS GATEWAY. FROM THE CAUSE AND CONSEQUENCES OF ONCO-DEVELOPMENTAL CHANGES IN GLYCOSYLATION TO PROTEINS THAT RECOGNIZE, BIND AND MEDIATE THE FUNCTIONS OF GLYCANS, STUDENTS ARE INTRODUCED TO ESSENTIAL CONCEPTS AND RECENT DEVELOPMENTS IN THE FIELD. CURRENT PURSUE IN BOTH BASIC RESEARCH AND MEDICAL APPLICATIONS, INCLUDING THE HISTORICAL DEVELOPMENT OF NEURAMINIDASE INHIBITORS (E.G. TAMIFLU) AND GLYCANS INVOLVED IN VIRAL INFECTIONS ARE DISCUSSED IN THE CONTEXT OF WHAT CHEMICAL APPROACHES ARE AVAILABLE TO GLYCOBIOLOGISTS FOR DIAGNOSTICS AND THERAPEUTICS. SEMINARS ARE ORGANIZED FOR STUDENTS IN GROUPS TO PRESENT AND DISCUSS KEY ORIGINAL RESEARCH PAPERS, WHICH TOGETHER WITH FOLLOWING UP WRITTEN REPORT, WILL CONSTITUTE THE PRINCIPAL COURSE WORK AND ASSESSMENT. 

課程目標
待補 
課程要求
待補 
預期每週課後學習時數
 
Office Hours
 
參考書目
ESSENTIALS OF GLYCOBIOLOGY 2ND EDITION 
指定閱讀
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
2/23  A Primer on Carbohydrate Structure and Conformation
(授課老師:Todd) 
第2週
3/02  Protein Glycosylation – From ER to Golgi
(授課老師:Khoo) 
第3週
3/09  Diverse range of O-glycosylation
(授課老師:Khoo) 
第4週
3/16  Analytical and Functional Glycomics
(授課老師:Khoo) 
第5週
3/23  Microbial Glycans and Biophysical Methods
(授課老師:Todd) 
第6週
3/30  Galectins – Outside and Inside
(授課老師:Angata) 
第7週
4/06  溫書假 
第8週
4/13  General Aspects of GBP and C-type Lectins
(授課老師:Angata) 
第9週
4/20  Mid Term Exam 
第10週
4/27  Siglecs and Sialylation
(授課老師:Angata) 
第11週
5/04  Chemical Glycosidic Bond Formation
(授課老師:Todd) 
第12週
5/11  Glycoenzymes: Synthesis, Mechanism and Inhibitors
(授課老師:Hans) 
第13週
5/18  Chemical and Translational Glycobiology I
(授課老師:Hans) 
第14週
5/25  Chemical and Translational Glycobiology II
(授課老師:Hans) 
第15週
6/01  Student Presentations
(授課老師:All) 
第16週
6/08  Student Presentations
(授課老師:All) 
第17週
6/15  Student Presentations
(授課老師:All)