課程資訊
課程名稱
去氧核糖核酸損傷、修復、和癌症
DNA Damage, Repair, and Cancer 
開課學期
108-2 
授課對象
生命科學院  生化科學研究所  
授課教師
冀宏源 
課號
BChem5047 
課程識別碼
B46 U1070 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期一6,7(13:20~15:10) 
上課地點
生化N101 
備註
與李弘文、詹迺立、林敬哲、吳青錫、張智芬合授
總人數上限:50人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1082BChem5047_ 
課程簡介影片
 
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課程概述

In this course, we will discuss the sources of DNA damage and how cells sense and respond to DNA lesions. Multiple DNA repair pathways, their discovery histories and new technologies for measuring DNA damages and repair will be covered in the lectures. Our genome integrity is maintained by a multitude of DNA repair and DNA damage response mechanisms. The failure of these mechanisms can result in a variety of diseases including cancer. The application of DNA damage and repair in therapeutic intervention in cancer and genome editing will be also introduced. 

課程目標
Through this course, students will be familiar with the fundamental knowledge of DNA damage, repair, and cancer. In addition, students will learn the classical and advanced methodology to study DNA damage and repair. We will also motivate students to ask questions and engage them to participate in the discussion. 
課程要求
We encourage students to take Biochemistry course before attending this class. 
預期每週課後學習時數
 
Office Hours
 
參考書目
1. Genome Stability, James E. Haber, 2014
2. Advanced review articles from each session 
指定閱讀
待補 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
3/02  I. DNA Damages and Repair systems
DNA damage sources and mutations
 
第2週
3/09  DNA repair systems 
第3週
3/16  DNA break repair  
第4週
3/23  Crosstalk between repair pathways  
第5週
3/30  Session I discussion  
第6週
4/06  溫書假 
第7週
4/13  II. Biophysical, Imaging and Structural Approaches to study DNA repair mechanisms
Tools to study protein-DNA binding
 
第8週
4/20  Single-molecule imaging tools 
第9週
4/27  Structural basis of nucleic acids processing 
第10週
5/04  Structural basis of DNA repair machineries 
第11週
5/11  Session II discussion 
第12週
5/18  III. DNA Repair and Cancer
Sensing DNA damage and the signal response
 
第13週
5/25  DNA damage response and cancer 
第14週
6/01  Genome instability of cancer 
第15週
6/08  DNA damage and repair in cancer therapy  
第16週
6/15  Session III discussion