The grand challenge in biology is not to achieve a deeper understanding of profound subjects. Instead, it matters so much more to make sure that science is taken seriously. Advances in technology typically outpace the public’s understanding of the underlying science, therefore lead to the public distrust and confusion about the actual benefits and risks involved. Popular culture, particularly movies, often misrepresent scientific facts for the purpose of entertainment is usually viewed as part of the problem. Some movies, however, offer excellent opportunities for teachers to draw connections and parallels between entertaining movie science and exciting real world science. This course was designed for non-biology major to illustrate how biology themes can be used to teach important ideas such as whether DNA is sufficient to create life, how life evolves, what is cloning, and how bionics could actually improve/impact our future life. Students will additionally explore public misconceptions and naiveté about science that are perpetuated by movies, as well as the extent to which such movies borrow from, or in some cases, even predict scientific fact. This course requires bi-weekly screenings of a feature-length movie prior to the lectures in the classroom. Films and topics are organized around biological themes: Discussion of films that feature different biological transformations will focus on distinguishing between science fiction and science fact, understanding the uses of the underlying principles in scientific research, and exploring real world analogies to such fictional concepts as fly-human chimeras and reconstructed dinosaurs.