Course Information
Course title
Signal Transduction in Diseases 
Semester
103-2 
Designated for
COLLEGE OF MEDICINE  GRADUATE INSTITUTE OF MICROBIOLOGY  
Instructor
CHING CHOW CHEN 
Curriculum Number
md&ph5040 
Curriculum Identity Number
420 U4400 
Class
 
Credits
Full/Half
Yr.
Half 
Required/
Elective
Elective 
Time
Friday 7,8 
Remarks
The upper limit of the number of students: 120. 
Ceiba Web Server
http://ceiba.ntu.edu.tw/1032md_ph5040_ 
Table of Core Capabilities and Curriculum Planning
Association has not been established
Course Syllabus
Please respect the intellectual property rights of others and do not copy any of the course information without permission
Course Description

訊息傳遞與疾病 

Course Objective
本課程旨在介紹細胞內分子訊息傳遞機制,闡明細胞功能的調節機制,進而認識疾病與其治療。課程內容涵蓋G-protein coupled receptors、small G proteins、signaling of receptor tyrosine kinases、regulation of transcription、signaling in immune system及腫瘤形成之相關訊息傳遞。本課程內容設計以教科書為主軸,輔以最新學術研究進展及臨床治療,希望幫助學生之研究和文獻閱讀能力。 
Course Requirement
 
Office Hours
 
References
1. Biochemistry of signal transduction and regulation / Gerhard Krauss. Weinheim :
Wiley-VCH Verlag GmbH & Co. KGaA, 2008. 4th
2. Signal transduction / Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R.
Tatham. Amsterdam ; Boston ; London : Elsevier/Academic Press, c2009. 2nd ed
 
Designated reading
待補 
Grading
   
Progress
Week
Date
Topic
第1週
02/27  請注意,本週不上課。 
第2週
3/06  Introducting:Basics of cell signaling 
第3週
3/13  G-protein coupled signal transmission pathways 
第4週
3/20  Intracellular messenger substances: “Second messengers” 
第5週
3/27  Transmembrane receptors with tyrosine kinase activity 
第6週
4/03  停課一周 
第7週
4/10  Signal transmission via Ras proteins 
第8週
4/17  Protein cascades of the Mitogen-activated protein kinase pathway 
第9週
4/24  Oncogenes and tumor suppressor genes 
第10週
5/01  Signaling in Immune system (I) 
第11週
5/08  Signaling to NF-κB: regulation by ubiquitination 
第12週
5/15  Signal Transduction in Immune System (II) 
第13週
5/22  Apoptosis 
第14週
5/29  Epigenetic mechanisms 
第15週
6/05  Cell adhesion and differentiation 
第16週
6/12  Targeting transduction pathways for research and medical intervention 
第17週
4/24  期中考成績